What is Hyaluronic Acid, and Why is It Important?
Hyaluronic acid, or HA, naturally occurring in the skin, eyes, and joints, can keep everything hydrated and smooth. On the skin, it acts like a microscopic sponge, absorbing and retaining water at a rate of up to a thousand times its weight! Therefore, it can be included in anti-aging treatments to diminish the appearance of wrinkles and restore the skin's youthful glow. As we become older, our bodies manufacture less hyaluronic acid, which leads to dry skin and aching joints.
Similar to how lubricant makes a machine run more smoothly, hyaluronic acid makes joints slide more easily, which in turn reduces pain and stiffness. In arthritis, hyaluronic acid injections can increase joint lubrication, but their efficiency is controversial, and results vary. It has multiple uses, including wound healing and keeping moisture in the eyes. You can find it in a variety of cosmetic products, from masks to lip fillers! Hyaluronic acid supplements benefits have an overwhelming amount of positive effects.
How Does Hyaluronic Acid Impact Skin Aging Processes?
Changes in HA directly relate to the loss of moisture experienced with aging. Particularly, the skin gets dry, and there is nothing to retain water when HA in the epidermis drops. Thus, HA in the dermis and in important parts of the epidermis determines skin moisture. Moreover, preserving this moisture depends much on the stratum granulosum, the outermost layer of the skin. The skin thus loses color, becomes dry, and becomes less flexible without HA, according to the study in the Dermato-Endocrinology(1). Generally speaking, two distinct factors contribute mostly to skin aging.
Inner Aging
The first thing that comes to mind when we talk about skin aging is the natural processes that come with age, that is, internal aging. This is a hormonal issue. For example, hormones such as estrogen and progesterone decrease with menopause. This leads to collagen breakdown, dry skin, loss of elasticity, and wrinkles. Here is where something intriguing happens: HA disappears in the epidermis, the top layer of the skin, but remains in the dermis, the bottom layer. Though the exact reason is unknown, HA synthesis in the epidermis is assumed to be regulated differently than in the dermis. The result? As a result of water loss, the outer layer dries out, skin gets dry, and wrinkles look worse.
External Aging
There is external aging, the biggest culprit of which is the UV rays of the sun. What happens to HA in this process called photoaging is a bit complicated. At first, UV rays initiate a mild wound-healing response in the skin, and HA increases in the dermis. But it doesn't stop there; repeated sun exposure reduces HA synthesis in dermal fibroblasts (skin cells). This is because collagen fragments suppress certain signaling pathways (e.g. Rho kinase signaling) and reduce the expression of the HAS-2 enzyme responsible for HA synthesis. We also see this in photoaged skin: HA molecules shrink; that is, fragmented HA with lower molecular mass accumulates.
Another quite crucial factor is HA's molecule size. Young skin has high molecular weight HA; this maintains the skin's integrity and helps to stop inflammation and vascularization. But HA contracts as we become older. These tiny HA fragments can function as the skin's stress signals, inducing inflammation and vascularization. Therefore, the indicators of aging get more prominent when HA's size drops.
The interaction between HA and skin receptors such as CD44 and RHAMM further hinders the skin's ability to repair and renew itself. These receptors play an essential role in cell adhesion and motility. But with aged skin, the expression of these receptors might degrade, which complicates the processes of skin's healing and regeneration.
How Collagen and Hyaluronic Acid Work Together?
Collagen and hyaluronic acid play crucial roles in wound healing and skin elasticity. Collagen is like a sturdy, long-lasting foundation; it forms the skin's architecture. Hyaluronic acid (HA) hydrates the skin, making it look young, plump, and smooth. Imagine collagen as the "skeleton" of the body and HA as the connective tissue that cushions and insulates the important fluids and nutrients that surround it. Combined, they maintain a youthful and radiant appearance of the skin.
This duo communicates with cells in different ways. Collagen allows cells to adhere and move with so-called integrin receptors, while HA regulates cell behavior with receptors such as CD44 and RHAMM. Collagen seems to be saying, "This is your place!" whereas HA is more like, "Relax, I am keeping the environment moist!" Together, they ensure that the cells are on solid ground and live happily.
When our tissues are damaged, this duo team immediately takes the stage. HA increases in the wound area, keeping the environment moist and accelerating healing. Collagen supports the formation of new tissue. For example, when there is a cut, HA provides moisture and soothes the area like a first aid team, while collagen strengthens the structure like a repair team. Together, they help tissues recover quickly.
Combining collagen and HA yields better results than using either one alone, according to the research in the RSC Advances(2). The study also emphasizes that using these two as a coating during the bone repair process after bone reinforcements are used in dental implants, for example, makes it much easier for cells to stick together, multiply, and form new bone. Working together yields better results every time!
Key Benefits of Collagen with Hyaluronic Acid
Collagen and hyaluronic acid (HA) have many benefits for both beauty and health. Below you can find the hyaluronic acid supplement benefits, how they work, and important tips on why they are so effective.
Improves Wound Healing and Skin Regeneration
Have you been cut, or is your skin healing slowly? Collagen accelerates the formation of new tissue and helps wounds to close. The body works like a repair team by sending collagen to the damaged area. HA promotes healing by encouraging the movement and proliferation of cells. Using collagen and HA shortens the period it takes for wounds to close by as much as 30%, according to studies in Medicine in Novel Technology and Devices(3) and PudMed Central(4).
Boosts Skin Hydration and Moisture Retention
Collagen and HA are synergistic in their support of skin health. Collagen aids in the retention of this moisture and keeps the skin's structural integrity, while HA draws water molecules into the skin and supplies hydration. Benefits of hyaluronic acid supplementation include the appearance of plumper, younger skin.
HA (Hyaluronic Acid) was found to increase skin moisture when taken orally, according to a 2023 study by Shanghai Jiao Tong University(5). In this study of 129 women, improvement in skin moisture was observed within 2-8 weeks in participants using HA supplements, and an increase in skin thickness was reported at the end of 12 weeks. Although there are no specific studies on the combined use of HA and collagen, the positive effects of both components on skin health are scientifically recognized.
Also, topical HA in a serum formulation provides excellent skin hydration, as demonstrated through clinical, photographic, chemical, and instrumental assessments, according to the study in the Dermatol Ther (Heidelb) involving forty women aged 30 to 65(6).
Supports Joint Health and Flexibility
The combination of collagen and hyaluronic acid supplements and vitamin C benefits our joints in numerous ways, including maintaining joint health and flexibility, easing morning joint stiffness, and enhancing athletic flexibility.
Collagen peptides, HA, and vitamin C were the subjects of one trial that examined their efficacy in alleviating persistent low back pain. Compared to those who only exercised, those who took this supplement had better pain relief and improved quality of life, according to the study in the Pro Research Analysis by Consensus. Plus, these advantages remained even after all this time!
There is also good news for those suffering from heel pain. The question of does ingesting collagen works for enhancing skin hydration and elasticity comes up often. A combination of collagen peptide type-1, HA, low molecular weight chondroitin sulfate, and vitamin C reduced pain and improved tendon structure in 12 weeks. Moreover, the study states that this effect is better than that of diclofenac sodium, a classic painkiller.
Strengthens Hair, Nails, and Connective Tissues
When it comes to hair, things might get trickier. Collagen can add strength to your hair since it supplies the amino acids required for keratin, the protein that makes up the hair shaft. However, scientists remain skeptical about this claim, with some asserting that collagen can enhance hair brightness or reduce brittleness. The skin around the hair follicles can still receive some assistance, which in turn might lessen hair loss.
When it comes to the nails, collagen does wonders. It has the potential to accelerate nail growth and decrease breakage. In persistent users, the rate of nail growth was 12%, and the rate of breaking was 42%, according to a study in the Nutrition & Food Sciences(7). It is a viable option to consider if your nails are prone to breaking quickly.
For connective tissues, things like tendons and ligaments, collagen is a real savior. It keeps these tissues strong and flexible, which is crucial as you age or perform activities. It works like glue to keep your body strong.
Of course, each person's body is unique, so an effective treatment for one may not have the same impact on another. But science is very promising for nails and connective tissues in particular. If you're curious, give it a try; your nails may rejoice, and your joints may feel a little more comfortable!
How to Use Collagen with Hyaluronic Acid Effectively?
Incorporating collagen and hyaluronic acid (HA) into your daily regimen is highly recommended. From nourishing your skin to bolstering your joints, this pair has you covered in more ways than one. However, what is the best way to put them to use?
1. Supplement Forms: Easy and Fast Solution
Supplements are a savior if you want to get collagen and HA into your body.
Here is how to use it:
- Collagen Peptides: Usually sold in powder, capsule or liquid form. You can mix the powdered ones in your morning smoothie, coffee, or water - no off-flavor! The capsules are super convenient to throw in your purse and go.
- Hyaluronic Acid: Mostly available in capsules or tablets. Great for moisturizing your skin and soothing your joints.
- Combined Use: There are supplements that combine both in one product. If you take it in the morning after breakfast, you will feel the effect all day long.
Remember to follow the dosage instructions. In general, 5–10 grams of collagen and 100–200 mg of HA should be taken daily. But read the instructions on the box of each product and act accordingly!
2. Topical Applications: Caring for Your Skin from the Outside
If you want to support your skin directly, creams and serums will be your best friends.
- Collagen-containing creams: Collagen peptide-containing creams help make your skin more elastic. Applying it twice a day, like a moisturizer, will be beneficial to your skin.
- Hyaluronic acid (HA) serums: HA is a skin-loving benefactor that binds water to the skin. If you apply the serum on clean skin and top it with a moisturizer, you'll feel instantly plump. Ideal to add to your morning and evening routine.
3. Food Sources: Strengthening Naturally
If supplements and creams are not enough, you can also get support from the kitchen.
- For Collagen: Bone broth, chicken skin, fish, and egg whites are natural collagen bombs. Having bone broth soup a few times a week or adding eggs to your menu is a great start.
- For HA: Citrus fruits, green leafy vegetables, and soy support HA synthesis. Invite oranges, spinach, or tofu to your table.
To get the maximum benefits of hyaluronic acid in collagen from this duo, the key is to be regular. Take supplements every day, keep up with your skincare, and pay attention to your diet. Don't expect miracles right away; this is a marathon, not a sprint. With a little patience, your skin and joints will thank you.
Frequently Asked Questions About Collagen and Hyaluronic Acid
Here are the FAQs about collagen and hyaluronic acid.
Can Collagen Supplements Have Any Negative Effects?
Though most of them are harmless, side effects might happen with collagen supplements. Some people could have constipation and bloating, among other digestive issues. Particularly among allergy patients, allergic responses to collagen generated from shellfish carry some danger. Changes in liver performance have seldom ever been documented. One should choose dependable companies since low-quality products may include dangerous metals. Before utilizing supplements, then, it is advisable to see a doctor.
What Is the Best Way to Take Collagen for Maximum Absorption?
To get the most out of collagen supplements, take collagen first thing in the morning, preferably on an empty stomach. Hydrolyzed collagen peptides are more easily absorbed by the body. Consuming it together with vitamin C increases its effectiveness by increasing collagen synthesis. It is ideal to take it with water; fatty foods should be avoided. The recommended daily dosage varies between 5-10 grams, but product instructions should be followed. These methods optimize absorption.
How Do Different Collagen Types Affect the Body?
Type I collagen is found in the skin, bones, and tendons; it tightens the skin and strengthens the bones. Collagen types have different functions in the body. Type II supports articular cartilage and contributes to joint health. Type III is located in the skin and blood vessels; it protects skin structure and improves vascular elasticity. A mixture of Types I and III is usually used in supplements, with Type II recommended for joints.
SOURCES
(1) - Hyaluronic acid A key molecule in skin aging Eleni Papakonstantinou, Michael Roth, George Karakiulakis, Dermato-Endocrinology 4:3, 253–258; July–December 2012; © 2012 Landes Bioscience
(2) - Haiyong Ao, ORCID logo, Chucheng Lin, Binen Nie, Shengbing Yang, Youtao Xie, Yizao Wan ORCID, Xuebin Zheng
(3) - Shang, L., Wang, Y., & Zhang, Y. (2024). Recent applications and molecular mechanisms of hyaluronic acid in skin aging and wound healing. Medicine in Novel Technology and Devices, 23, 100036.
(4) - Mathew-Steiner SS, Roy S, Sen CK. Collagen in Wound Healing. Bioengineering (Basel). 2021 May 11;8(5):63. doi: 10.3390/bioengineering8050063. PMID: 34064689; PMCID: PMC8151502.
(5) - Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test Yan-Rui Gao, Rui-Ping Wang, Lu Zhang, Yuan Fan, Jin Luan, Zhe Liu, Chao Yuan First published: 20 November 2023
(6) - Draelos ZD, Diaz I, Namkoong J, Wu J, Boyd T. Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging. Dermatol Ther (Heidelb). 2021 Aug;11(4):1385-1394. doi: 10.1007/s13555-021-00566-0. Epub 2021 Jun 26. PMID: 34176098; PMCID: PMC8322246.
(7) - A Nutritional Supplement Formulated with Peptides, Lipids, Collagen and Hyaluronic Acid Optimizes Key Aspects of Physical Appearance in Nails, Hair and Skin Michelle R. Yagoda, Eugene H. Gans Nutrition & Food Sciences Yagoda and Gans, J Nutr Food Sci 2014
Scientifically Reviwed by Omer (Matt) Sermet
